Reduced metastatic tumor burden in intraocular melanoma-bearing mice receiving AdCMV-PAI-1 gene transfer. 99E1 murine uveal melanoma cells were transplanted IC into BALB/c nude mice on day 0. On days 7 and 9, mice received IC inocula containing either AdCMV-PAI-1 or AdCMV-βGal. Mice were euthanized on day 49 and their livers removed. The metastatic tumor mass in the liver was quantified by a capture ELISA. Results are expressed as mean ± SEM. There were 10 animals in each group. AdCMV-PAI-1 group was significantly different (P = .001) from untreated and AdCMV-βGal–treated groups (Student's t-test).