Effect of AdCMV-PAI-1 gene transfer on survival of intraocular melanoma-bearing mice. BALB/c nude mice bearing intraocular OCM-1 human uveal melanomas were treated with: (A) two IC inoculations of either AdCMV-βGal or AdCMV-PAI-1 on days 7 and 9 post IC tumor inoculation or (B) three IV inoculations of either AdCMV-PAI-1 or AdCMV-βGal on days 21, 28, and 35 post IC tumor inoculation. There were 10 mice per group. AdCMV-PAI-1 treated groups were significantly different from untreated controls in both experiments (A, P = .001 and B, P = .007) using Wilcoxon's test.