Fig. 1.
Effect of irradiated A20 cells mixed with gene-modified fibroblasts expressing CD40L or IL-2 on the growth of preexisting tumor. Four groups of mice (seven per group) were challenged with 105 A20 cells on day 1. On days 4 and 14, mice received SQ injection of 105 A20 cells mixed with 2 × 105 transduced CL7.1 fibroblasts expressing either the CD40L or IL-2 gene, or neo (control). Before injection, the cell mixture was irradiated to 1,000 cGy. The fourth group of mice was treated with irradiated A20 cells and a combination of fibroblasts expressing either CD40L or IL-2. Tumor volumes are shown as the mean mm3 ± standard error of mean (SEM).
