Photomicrographs of (a) normal palpebral conjunctiva from a Plg^+/− mouse in contrast with (b through h) Plg^−/− mice. (b) Large eosinophilic deposits with low cellular density constitute the majority of the area occupied by lesions. (c) Disrupted epithelium was associated with (d) amorphous PAS⁺ material (in the same lesion). (e) The amorphous material stained with an anti-mouse Fib antiserum (top) but not with normal rabbit serum (bottom; arrowheads indicate lesion area). (f) An acute inflammatory infiltrate with prominent neutrophils (arrows) is adjacent to amorphous, eosinophilic material. (g) Epithelial cells, including PAS⁺ goblet cells, existing as a discreet cluster (*) inside the eyelid show the degree of disorganization of the epithelium. (h) Reduplication of the epithelium (denoted by “e”) occurred adjacent to eosinophilic deposits. Panels b, c, and h are hematoxylin and eosin preparations; panels a, d, and g are PAS preparations; panel f is a Leder stain. Original magnifications are 100× (panels b and e), 200× (panels a, c, d, g, and h) and 400× (panel f).