Fig. 2.
Fig. 2. Effect of culture with MDM2 antisense ODN on expression of MDM2, p53, E2F-1, CDK4, and p21 proteins in RPMI 8226 MM cells. RPMI 8226 MM cells were cultured in media alone or with MDM2 antisense, sense, or nonsense ODNs for 4 hours. Total cell lysates were immunoprecipitated and immunoblotted with SMP14 anti-MDM2 MoAb, AB-6 anti-ptp53 MoAb, C-20 anti–E2F-1 MoAb, H-22 anti-CDK4 pAb, and C-19 anti-p21 pAb.

Effect of culture with MDM2 antisense ODN on expression of MDM2, p53, E2F-1, CDK4, and p21 proteins in RPMI 8226 MM cells. RPMI 8226 MM cells were cultured in media alone or with MDM2 antisense, sense, or nonsense ODNs for 4 hours. Total cell lysates were immunoprecipitated and immunoblotted with SMP14 anti-MDM2 MoAb, AB-6 anti-ptp53 MoAb, C-20 anti–E2F-1 MoAb, H-22 anti-CDK4 pAb, and C-19 anti-p21 pAb.

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