Concentration-dependent effects of the soluble guanylyl cyclase inhibitor LY83583 on human monocyte migration elicited by Lp(a) (300 μg/mL). Monocytes were preincubated with LY83583 for 15 minutes before addition of the chemoattractant Lp(a) (300 μg/mL). When the stable cGMP analog 8-pCPT-cGMP was used, the compound was added together with Lp(a) to the lower compartment of the chemotaxis chamber. *P < .05 and **P < .01 versus Lp(a) (300 μg/mL). Cell numbers are expressed as mean ± SEM per high-power field of four independent experiments.