A schematic representation of events in the M1 cell nucleus which stem from the LIF receptor complex, highlighting the involvement of WT1 +KTS isoforms in the direct, or indirect, regulation of lineage-specific genes, and the suggestion of a separate LIF-induced pathway of programmed cell death. The role of WT1 −KTS isoforms in this pathway, and the potential for interactions between ±KTS isoforms of WT1, is unclear.