American Society of Hematology

Fig. 3.

$Fig. 3. Dimerization of c-kit is sufficient for proliferative signaling. MTT assays were performed on five Ba/F3 clones expressing the construct F1c-kit432 in the absence of IL-3 and in the presence of increasing concentrations of either FK1012 (upper panel) or AP1510 (lower panel). Results are plotted as a fraction of the OD570-630 measured from the same cells cultured in 5% WEHI conditioned medium. Data points indicate mean values of three separate experiments. Error bars indicate standard deviations. Note that the level of cell proliferation observed is slightly reduced compared with Ba/F3 cell clones expressing the F3c-kit432 construct.$

Dimerization of c-kit is sufficient for proliferative signaling. MTT assays were performed on five Ba/F3 clones expressing the construct F1c-kit432 in the absence of IL-3 and in the presence of increasing concentrations of either FK1012 (upper panel) or AP1510 (lower panel). Results are plotted as a fraction of the OD570-630 measured from the same cells cultured in 5% WEHI conditioned medium. Data points indicate mean values of three separate experiments. Error bars indicate standard deviations. Note that the level of cell proliferation observed is slightly reduced compared with Ba/F3 cell clones expressing the F3c-kit432 construct.

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