Interphase nuclei of a t(8;14)⁺ Burkitt's type ALL. Two interphase nuclei meeting the type I hybridization pattern show three red signals (c-myc-split, arrowhead) and colocalization (arrow) of one of these signals with a green COS-cα1 signal indicative for a t(8;14). Small picture: t(8;14)⁻ control metaphase showing the location of the FISH probes. Distinct red (c-myc) and green (IgH) signals can be detected in the region 8q24 and 14q32, respectively.