Fig. 2.
![Fig. 2. Reduction of the inner mitochondrial membrane potential (▵ΨM, A) and production of ROS (B) in untreated control or Ara-C–treated (4 hours) HL-60/neo, HL-60/Bcr-Abl, and K562 cells. Ara-C treatment increased the percentage of HL-60/neo, but not HL-60/Bcr-Abl or K562 cells, which displayed either low ▵ΨM (DiOC6[3] uptake) or high ROS production (staining by DCFH-DA). The open peak (indicated by the arrow) represents the positive control after treatment with 10 mmol/L H2O2.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/91/5/10.1182_blood.v91.5.1700/3/blod4050302.jpeg?Expires=1742852336&Signature=3QX~CQwuJGqivG4f6oN2Sh~PkWeT4XOxkBaoCqsMxOhS3z3~Qsz80DRytoipSNZUUEj0eDFpUj6DBA2k-5pTmkp8~vFWzJGF1csSF1FdtAAaiAIP3pE3jgtBBZQR~cpOVDcJBYjO5JCAgKUDU1tF4Bet~u9ZmTnN4jIuDoLZKv5gMWNOmi3PikdTvf1C45kKRYZHdSdZyhMYACr75oeuvKJo9waDiQ0oadmRN3nHA~hoyDpZ3ofODXXr1~7s3IzNi7OU-MFodt7onwVsW-f9y5XMe0WB-dAL8UjE9e8O3ZQMLELAnQJfr7frnafwEIyPJpXJ8IrXptJrYlyGKuUEWw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Reduction of the inner mitochondrial membrane potential (▵ΨM, A) and production of ROS (B) in untreated control or Ara-C–treated (4 hours) HL-60/neo, HL-60/Bcr-Abl, and K562 cells. Ara-C treatment increased the percentage of HL-60/neo, but not HL-60/Bcr-Abl or K562 cells, which displayed either low ▵ΨM (DiOC6[3] uptake) or high ROS production (staining by DCFH-DA). The open peak (indicated by the arrow) represents the positive control after treatment with 10 mmol/L H2O2.
