UPN 386 received a T-cell–depleted, unrelated donor bone marrow transplant for acute myelogenous leukemia and developed fever 12 weeks posttransplant. There was no evidence of EBV-LPD on computerized tomography, but levels of EBV DNA were 40,000 copies/μg DNA. This patient was noted to have relapsed leukemia at this time, received a donor leukocyte infusion, and had a decrease in EBV DNA to the normal range.