Correlates of red blood cell and platelet transfusion requirements. Transfusion requirements were of interest in patients with AL undergoing dose-intensive therapy because of the association between AL, coagulation abnormalities, and vascular pathology. (A) Patients with higher marrow amyloid grades required more red blood cell transfusion support, a correlation identified initially by simple regression analysis (R² = .46, P < .01). (B) Patients with higher grades of edema during the myelosuppressive period, caused by combinations of salt avidity, hypoalbuminemia, autonomic dysfunction, sepsis, or low cardiac output, required more platelet transfusions, perhaps because of increased vascular injury. This correlation was also identified initially by simple regression analysis (R² = .31, P < .01). Peripheral edema was graded clinically by SWOG criteria. Values are medians and ranges.