Fig. 2.
Scatter of TRF with age in normals and patients. TRF values from unfractionated peripheral blood leukocytes plotted against age in years at last birthday. Results from normal donors (n = 60; ▵) show a progressive shortening of TRF with age. The regression line for normals is shown as a solid line, and the 95% confidence limits are shown as broken lines (r = −.838, P < .0001). The slope equates to a telomere loss of 36 bp per year. (⧫) TRF values for patients (n = 79).