Growth-stimulating activities toward HEL cells of various anti-adhesion molecule MoAbs. Induction of³H-thymidine-incorporation of HEL cells by MoAbs against integrin β chains (A) and integrin β2 subfamily (B). Anti-adhesion molecule MoAbs were added at the final concentration of 10 μg/ml to 5 × 10³ cells/well of 96-well type culture plates of HEL cells in 200 μL of RPMI-1640 medium supplemented with 0.1% (wt/vol) BSA in triplicate. Growth-stimulating activity was measured by assaying³H-thymidine incorporation by HEL cells as described under Materials and Methods. The MoAbs used and their clone names are indicated below the bars in the figure. The results are expressed as mean values ± SD of the mean.