Serial effects of a single intravenous dose, 25 μg/kg (○) or 250 μg/kg (•) of PEG-rmMGDF administered on day 0 on MPV in mice. PEG-rmMGDF caused a dose-dependent increase in MPV, which began on day 2 and peaked on day 4. Each data point represents the mean ± SEM of MPV; for the 25 μg/kg dose, n =4 to 10 mice per time point for the MGDF group and n = 13 for controls, and for the 250 μg/kg dose, n = 5 to 7 mice per time point for the MGDF group and n = 18 for controls. Data from control mice were pooled to represent the day 0 data point.