Fig. 5.
![Fig. 5. Transmission electron micrographs of platelets from mice on day 4 after receiving carrier only (a and c) or a single intravenous dose of 250 μg/kg of PEG-rmMGDF (b, d, and e). Platelets produced in response to PEG-rmMGDF had normal ultrastructure, with the exception of frequent endoplasmic reticulum (arrowheads in [d] and [e]) and Golgi Complex profiles in platelet sections, suggesting their premature release. db, dense bodies; g, alpha granule. Magnification in (a) and (b) × 13,000, and in (c), (d), and (e) × 34,000.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/91/2/10.1182_blood.v91.2.466/3/blod4021205.jpeg?Expires=1735522094&Signature=RUt~Fl5U00JJtjD0ujcAgl50iS~GXjGzn85VQ6QBlT5jAzeiWv97OX1hQ56mRLNWG4G4ojnCQL~7Z9Q1LjMenMcma0CmZqLQ4wi59E-nodRcW~YgLMcL5yZUCoImalimDv-BiTmkFbgjnIo3uvt95dtvDUHk2Dxce4eE-UqDkz~m5uPnBNWPjTZXE8uHGdjHQSRM96R3LoN7P0uye~XnSseHkEeujuvQG-liJtU4i4bSIyWKIj73wViDfWmLCTblE-Ztj7EGDkpjvaKiU4raCPGfVgBUL-FUItFn5XBe7UdHwlKkrMVcmIS7WCxXsMdaYladaPUHjLPA8nNcNQaS5Q__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Transmission electron micrographs of platelets from mice on day 4 after receiving carrier only (a and c) or a single intravenous dose of 250 μg/kg of PEG-rmMGDF (b, d, and e). Platelets produced in response to PEG-rmMGDF had normal ultrastructure, with the exception of frequent endoplasmic reticulum (arrowheads in [d] and [e]) and Golgi Complex profiles in platelet sections, suggesting their premature release. db, dense bodies; g, alpha granule. Magnification in (a) and (b) × 13,000, and in (c), (d), and (e) × 34,000.
