CDR3 nucleotide sequences. The clonal CDR3 sequences in the second biopsies are compared with those identified in the initial biopsies. Whether the sequences were derived from directly sequencing FW3-JH1 PCR products or from sequence analysis of individual clones of FW3-JH1 products is indicated in parentheses along with the number of related clones to total clones analyzed. N nucleodies are shown in lower case, whereas D and J segments are shown as boldface capitols (J segments left most). Nucleotide differences from the proposed germline D and J segments are underlined. (The names of the D and J segments are given in Table 3.)