(A) Comparison of hematologic parameters in the transgenic mice (Tg, ○) and nontransgenic controls (C, •) from 4 months to 8 months after birth. The data of mean values and standard deviations for groups of four mice are shown. (B) WG-stained peripheral blood smears of a transgenic mouse (Tg) and a nontransgenic control (C) at 4, 6, and 8 months after birth. A cell morphologically resembling megakaryocyte is indicated by an arrowhead. (C) Family tree derived from a founder mouse, 4-5. Circles and squares indicate female and male mice, respectively. Transgenic or nontransgenic mice are shown as transgene + or −. Mice that died of leukemia are shown as • or ▪.