The effect of vitamin E on thrombin generation supported by LDL. LDL from 9 subjects was incubated with or without vitamin E for 30 minutes before oxidation for 17 to 20 hours at 37°C. LDL with no additions and LDL incubated only with vitamin E were also prepared. Thrombin generation potential was quantified as described previously. The results are expressed as nmol/L thrombin, calculated from the standard curve generated with α thrombin. *Thrombin generation supported by oxidized LDL was increased compared to each of the other three groups (LDL + copper v LDL, P < .0001; LDL + copper v  LDL and vitamin E, P < .0001; LDL + copper v  LDL + vitamin E + copper,P < .0001).