Fig. 7.
![Fig. 7. The IFN-γ–induced increase in high-affinity IL-12 receptor expression is mediated by IL-12. PBMC were activated with PHA, PHA + IFN-γ, or PHA + IFN-γ + anti–IL-12. Binding studies using [125I]–IL-12 were performed and the results analyzed using the Scatchard method. Similar results were obtained in three separate experiments.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/91/4/10.1182_blood.v91.4.1341/4/blod4041007.jpeg?Expires=1735824827&Signature=ydKcPbAThyq74Mjmg3xtvGl1owsZjY~yjeqZ428PdoJG1BdGcPVogDKL59-iENX~owSFXSO6eGUx9TwXMUCcf96A7x9Tn0GvhKlZ6-tNKlQNKdtQQp3baOhe3BRGpxrN3lCRUoLIg2ywzj02UxlJ9~fVkbSV1HE5tfE4TpB-8p5sbpwSn4LnJxIw5NQygd9XcdxEIXDVnZOI-hGFslX0DeUxtzBSzrskkyCBLwbPbeIaBOrui4fsh8iaosfwMNSSGzgqsI5aQymScQL6qZBbDV6sqmj~5ow4n9Yj8L9nNkTmGBoHLumGSkKhwt1nkNo01x7aggYc9CwZM7J6xDLyaA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
The IFN-γ–induced increase in high-affinity IL-12 receptor expression is mediated by IL-12. PBMC were activated with PHA, PHA + IFN-γ, or PHA + IFN-γ + anti–IL-12. Binding studies using [125I]–IL-12 were performed and the results analyzed using the Scatchard method. Similar results were obtained in three separate experiments.
