Effects of sLe^x and CGP69669A on surgically stimulated, P-selectin–dependent leukocyte rolling in vivo. Mouse cremaster muscle was prepared for intravital microscopy and superfused with bicarbonate buffer for 30 minutes to produce P-selectin–dependent rolling. Shown are the effects on leukocyte rolling flux of treatment with sLe^x (100 mg/kg), CGP69669A (100 mg/kg), and anti–P-selectin antibody RB40.34 (10 μg). Data are presented as the mean ±SEM of values from at least 9 venules from 3 or 4 mice per treatment group. **Significantly different from control (P< .01).