Correlation between the inhibition of PL metabolism and the inhibition of parasite growth. PL50 and IC50 (concentration producing 50% inhibition of PL synthesis and parasite growth, respectively) measured as described in the Materials and Methods were from Table 1. PL50 values correspond to high hematocrit level conditions (Table 2). The 50 compounds considered for this correlation are in bold characters and underlined in Table 1. Squares correspond to compounds for which a hematocrit-dependent effect on PL metabolism was demonstrated (▪) or probable (□). Diamonds indicate compounds for which no hematocrit-dependent effect was demonstrated (⧫) or probable (◊ ), and (×) stands for compounds of group H for which a hematocrit level effect was not determined. The dotted line corresponds to the theoretical line when PL50 = IC50 (slope = 1, ordinate at the origin = 0).
