Effect of human IL-6 antisense oligonucleotides on clonal growth of KSHV-infected lymphoma cell lines. The PEL cell lines (A), KS-1; (B), BC-1, and the KSHV-negative lymphoma cell line (C), EW36 were cultured in soft agar with human IL-6 sense (□), scramble (C-1) (○), or antisense (◊)phosphorotioated oligonucleotides at 1, 5, and 10 μmol/L. Results were expressed as a percentage of control cells not exposed to oligonucleotides; results represent the mean ± SD of three experiments done in triplicate. Results with another scramble oligonucleotide (C-2, ≤ 10 μmol/L) showed similar results as the C-1 scramble oligonucleotides.