Lymphoma colonies formed by the BC-1 cells treated with either sense or antisense IL-6 oligonucleotides. Cells were plated at 5,000 cells/mL and cultured for 14 days with either IL-6 sense (10 μmol/L) (A) or IL-6 antisense oligonucleotides (10 μmol/L) (B). Colony formation was almost completely inhibited in cultures containing IL-6 antisense oligonucleotides.