An ICE inhibitor, but not IL-1Ra, reduces LPS-induced IFNγ production. Splenocytes from WT mice were incubated with LPS alone (1 μg/mL) or with LPS the presence of either IL-1Ra (10 μg/mL) or of an ICE inhibitor (20 μmol/L). IFNγ levels were measured 24 hours later. Data are the mean ± SEM of 6 mice per group. **P < .01 versus LPS alone by ANOVA for repeated measures.