Time course of IFNγ production in splenocytes from WT and ICE-deficient mice. Splenocytes from WT (•) or ICE-deficient (○) mice were incubated for the indicated times with 1 μg/mL of LPS (A), 10 μg/mL of zymosan (B), or 1 μg/mL of ConA (C) and levels of IFNγ were measured. Data are the mean ± SEM of 6 mice per group. *P < .05 versus WT by factorial ANOVA.