Increased LPS-induced spleen cell proliferation in ICE-deficient mice. Splenocytes from WT (•) or ICE-deficient (○) mice were incubated for 72 hours with the indicated concentrations of LPS (A) or Con A (B) and proliferation was assessed. Lymph node cells from WT and ICE-deficient mice immunized 14 days before with ovalbumin were incubated for 72 hours with the indicated concentrations of ovalbumin and proliferation was assessed (C). Data are the mean ± SEM of 6 mice per group and are expressed as the percentage of change in MTS absorbance compared with unstimulated cells (100%). ***P< .001 versus WT by factorial ANOVA.