Fig. 3.
Fig. 3. Psoralen-DNA adduct formation following photochemical treatment with various psoralens in platelet concentrates. Psoralen adducts on leukocyte genomic DNA were measured after photochemical treatment in pooled random donor platelet concentrates by using3H radiolabeled S-59 (□), AMT (▴), and 8-MOP (○) plus 1.9 Joules/cm2 UVA. Photochemical treatment with 150 μmol/L S-59, AMT, and 8-MOP induced 12.0 ± 3.0, 6.0 ± 0.9, and 0.7 adducts/1,000 bp of DNA, respectively. Points with error bars (standard deviation) represent averages of duplicate samples obtained from two independent experiments.

Psoralen-DNA adduct formation following photochemical treatment with various psoralens in platelet concentrates. Psoralen adducts on leukocyte genomic DNA were measured after photochemical treatment in pooled random donor platelet concentrates by using3H radiolabeled S-59 (□), AMT (▴), and 8-MOP (○) plus 1.9 Joules/cm2 UVA. Photochemical treatment with 150 μmol/L S-59, AMT, and 8-MOP induced 12.0 ± 3.0, 6.0 ± 0.9, and 0.7 adducts/1,000 bp of DNA, respectively. Points with error bars (standard deviation) represent averages of duplicate samples obtained from two independent experiments.

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