Changes of coagulation markers in newly diagnosed APL patients (n = 9) receiving ATRA for induction therapy. Results are the median values of fibrinogen, D-dimer, and thrombin-antithrombin complex (TAT) at different intervals during the first 2 weeks of treatment. Dashed lines are: fibrinogen = the lower limit of normal control values; D-dimer and TAT = the mean + 2 SD (cut-off point) of normal control values. (Modified and reprinted with permission.15)