Anti–BCR-ABL AS-ODNs restore CML CFC adhesion to and proliferation inhibition by fibronectin significantly more than control ODNs. A total of 10,000 DR⁺ cells were incubated in serum-free medium for 96 hours with or without addition of breakpoint-specific and control ODNs. After incubation, cells were either kept in suspension or were cocultured with FN substrates, and their adhesion and proliferation were evaluated as described in the text. Results represent the mean ± SEM for four separate experiments.