Fig. 1.
Fig. 1. (A) Southern Blot analysis. Genomic DNA from four controls (lanes 1-4) and the inv(8) patient (lane 5) were digested withBglII (i-iii) or EcoRI (iv-vi) and probed with MOZ 0.9, MOZ I, and UN-1 as indicated. Germline bands were present in all samples and an additional band was seen for the patient for all enzyme/probe combinations except EcoRI/MOZ 0.9. (B) Schematic representation of the two sequenced bacteriophage λ clones. The 7-kb and 5.1-kb BglII fragments were derived from the germline and rearranged bands, respectively. The last MOZ exon is shown as a filled box and intron sequence as a line. The positions of the probes MOZ 0.9, MOZ I, and UN-1 are indicated. The breakpoint in the 5.1-kb clone coincides with the EcoRI site within the last exon of MOZ, 47 bp downstream of the MOZ intron-exon junction.

(A) Southern Blot analysis. Genomic DNA from four controls (lanes 1-4) and the inv(8) patient (lane 5) were digested withBglII (i-iii) or EcoRI (iv-vi) and probed with MOZ 0.9, MOZ I, and UN-1 as indicated. Germline bands were present in all samples and an additional band was seen for the patient for all enzyme/probe combinations except EcoRI/MOZ 0.9. (B) Schematic representation of the two sequenced bacteriophage λ clones. The 7-kb and 5.1-kb BglII fragments were derived from the germline and rearranged bands, respectively. The last MOZ exon is shown as a filled box and intron sequence as a line. The positions of the probes MOZ 0.9, MOZ I, and UN-1 are indicated. The breakpoint in the 5.1-kb clone coincides with the EcoRI site within the last exon of MOZ, 47 bp downstream of the MOZ intron-exon junction.

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