(A) Sequence surrounding the MOZ-TIF2 fusion. Nucleotide 3745 of MOZ was joined to nucleotide 2768 ofTIF2. The underlined sequence indicates the region withinTIF2 that is alternatively spliced in both the normal and fusion genes. (B) RT-PCR analysis of bone marrow RNA from a normal individual and the patient with the inv(8). Normal MOZ andTIF2 transcripts were detected in both samples, the lowerTIF2 band resulting from alternative splicing. TheMOZ-TIF2 fusion was seen only in the patient and reciprocalTIF2-MOZ transcripts were not detected. The identity of all bands was confirmed by sequencing. M, 123-bp molecular weight marker.