Deletions within the rearranged IgV_H gene of case 3.

Two deletions (indicated by dots and gray background) are detectable: a 19-bp deletion is found at the border between FR1 and CDR1 involving codons 26 through 31a of the corresponding V4-30.4 germline sequence, and an 8-bp deletion is detectable within FR3 (codons 72 through 75). Identities to the closest germline sequence V4-30.4 are indicated by dashes, and each mutation is shown by the appropriate nucleotide. Stop codons are marked by asterisks. The numbering refers to codons counted from the beginning of V_H according to Chothia et al.58