Time from molecular relapse detection to clinical relapse.

Longitudinal RT-PCR results from bone marrow aspirates of 7 patients who attained a molecular remission but later relapsed are shown. Each circle represents an assay performed at the indicated time after achieving clinical complete remission. Only samples with adequate RNA quality for amplification of control RNA are included. ● denotes a positive assay; ○ denotes a negative assay. Periods of consolidation therapy with chemotherapy or humanized anti-CD33 monoclonal antibody HuM195 are shown by the shaded bars. Arrows indicate the time of clinical relapse.