Fig. 6.
Fig. 6. Kinetics of R-CDC–induced ROS production, loss of Δψm, and phosphatidylserine exposure. / (A) The kinetics of ROS generation were analyzed in cells from a patient with MCL with CD20++ expression (119 × 103 CD20 molecules/cell) as described in “Patients, materials, and methods.” (B) Time-course of ROS production (solid line), loss of ΔΨm (dashed line), and annexin V exposure (dotted line) in cells from a patient with MCL with very high levels of CD20 (137 × 103 molecules/cell) (top panel) and a CD20++ patient with B-CLL with high levels of CD20 (70 × 103 molecules/cell) (lower panel).

Kinetics of R-CDC–induced ROS production, loss of Δψm, and phosphatidylserine exposure.

(A) The kinetics of ROS generation were analyzed in cells from a patient with MCL with CD20++ expression (119 × 103 CD20 molecules/cell) as described in “Patients, materials, and methods.” (B) Time-course of ROS production (solid line), loss of ΔΨm (dashed line), and annexin V exposure (dotted line) in cells from a patient with MCL with very high levels of CD20 (137 × 103 molecules/cell) (top panel) and a CD20++ patient with B-CLL with high levels of CD20 (70 × 103 molecules/cell) (lower panel).

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