Analysis of HVR1 aa sequence in clones derived from plasma of patients with and without MC2.

(A) Alignment of HVR1 aa sequences (codons 384-410) of individual clones derived from the plasma of 21 patients with MC2. Dots indicate nucleotide sequence identity with the consensus sequence reported on the top line.19 In patients 1 to 5, dashes indicate the sites of aa insertion as compared to the consensus; in patient 6, a slash denotes deletion. For each patient, the number of clones with identical sequences is indicated on the right. (B) Alignment of HVR1 aa sequences (codons 384-410) of individual clones derived from plasma of a control group of 20 patients with no MC2. Dots indicate nucleotide sequence identity, with the consensus sequence reported on the top line. For each patient, the number of clones with identical sequences is indicated on the right.