Fig. 4.
![Fig. 4. Rolipram raises cAMP levels in CLL cells, WMC, and resting B cells. One million freshly isolated cells were incubated with the indicated drugs for 2 hours before analysis of cAMP in cell lysates using a radioimmunoassay. Data are the mean of three individually assayed culture wells. In (D), vinpocetine was added at 30 μmol/L. The experimental conditions indicated with an asterisk had a greater [cAMP] than, as appropriate, the untreated or forskolin-treated control cells (t-test: one-tailed significance level <.05).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/92/7/10.1182_blood.v92.7.2484/3/blod41921004x.jpeg?Expires=1735555142&Signature=jlUtORKK-QTRqmL4kos-IqK5dKFnIdNz9j~KrSmFGND5Fo9LDe8UnN4vOy~FuiywdH2w0K0WwL52a6VASjPCv1w5n2WWfwW0fpvOf1dQm2HUE5mBdHC87zZLCoaMw0xhwzhF2MjKPAm3ZYlKyhfwdv5UFqZ~6mF4hNDzbKjG4JipnMybUNopesQvwKyzW~l9BF1ut9ZhpMOzz9g-pO20M3J7dK81FYr0glx8AZPz6-H4hGee0op1hybMmWflf4zCPwkwJq5j-h1VcVckwoZY5iAPETh-yGtbd9hd5T1O8i~NJTMYoIqlLtB1I7YkN~8jdCJqnRsVQrhBoRACABGMaw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Rolipram raises cAMP levels in CLL cells, WMC, and resting B cells. One million freshly isolated cells were incubated with the indicated drugs for 2 hours before analysis of cAMP in cell lysates using a radioimmunoassay. Data are the mean of three individually assayed culture wells. In (D), vinpocetine was added at 30 μmol/L. The experimental conditions indicated with an asterisk had a greater [cAMP] than, as appropriate, the untreated or forskolin-treated control cells (t-test: one-tailed significance level <.05).
