Integration of platelet transcript and protein profiling to study human diseases. The combination of proteomic and transcriptomic technologies can be applied for comparative studies between normal and diseased platelets, ultimately leading to novel diagnostic assays or to the identification of novel therapeutic targets. Potential applications include treatment of not only single-gene platelet disorders but also the broader subset of patients with platelet-related cardiovascular or cerebrovascular disease. The box summarizes current limitations and progress achieved to date.