Significant gene derepression in Ik^L/L BM pDCs. (A) Representative scatterplots comparing the gene expression profile between 2 independent WT samples (top), versus a WT and an Ik^L/L sample (bottom). The right panels are enlargements of boxed areas in the left panels. Red indicates increased genes; blue, decreased genes. (B) Genes that either “increased” or “decreased” in all of the 9 Ik^L/L/WT comparisons were selected and grouped according to the magnitude of change (average of the “fold change” [in log2] from all 9 comparisons). Note that the decreased genes exhibited mostly modest variations, while many increased genes exhibited large variations. ▦ correspond to the estimated number of nonspecific changes (“Materials and methods”). (C) Number of up-regulated genes in Ik^L/L samples whose expression was not detected in WT samples (▪) or were expressed in WT but not detected in Ik^L/L samples (□).