Preferential pattern of NFAT and NF-κB transcriptional pathway targeting by CPS11, CPS45, and CPS49. (A) Plotting of the magnitude (y-axis) of the Eigenvector coefficients (x-axis) derived from PC1 reveals strong anticorrelated contribution from NF-κB and NFAT pathways. (B) PCA of the drug influence on each of the 16 mitogen-induced transcriptional responses mapped by biplot analysis.¹²  Ellipses enclose 2 SDs from the mean effect of each drug group. (C) Histogram analysis of the drug-influenced NFAT and NF-κB reporter activity. Stimulation conditions are indicated by number assignment in the key. Results are representative of triplicate determinations. The average percentage of error for the transfections was 6.6%.