Concentrations of 4 individual discriminator proteins, their receiver operating characteristic (ROC) curves, and the composite panel ROC curves. (A) Absolute values on a logarithmic scale of soluble IL-2Rα, TNFR1, HGF, and IL-8 in samples from the training with their medians and ranges. Patients without GVHD (−) versus with GVHD (+): P < .001. (B) Individual ROC curves for IL-2Rα (----), TNFR1 (—), HGF (.-.-.), and IL-8 (.....) and the composite panel (—). (C) ROC curves of the composite panel for the training set (—) and the validation set (- - - -). The cross separates patients into 2 groups based on their predicted probability of GVHD (high and low) with a specificity of 95% in the training set and 94% in the validation set.