Dynamics of CD4⁺ and CD8⁺ T-cell immune activation in rituximab-infused RMs and controls. Immune activation (as defined by changes in the expression of -DR markers) in blood (A,B), lymph nodes (C,D), and intestine (E,F) in rituximab-infused RMs with complete CD20 depletion (■), incomplete tissue CD20 depletion (▾), and in control RMs (●). Plots represent the average expression for the animals in each study group. Vertical lines represent the SEM.