The role of Lyn and Fyn in botrocetin/VWF-induced integrin-dependent platelet aggregation. (A) Washed wild-type and Lyn−/− mouse platelets and (B) washed wild-type and Fyn−/− mouse platelets were stimulated with botrocetin (1.2 μg/mL) and VWF (10 μg/mL) at 37°C. Platelet aggregation was monitored using a turbidometric aggregometer.