DFS by TP1 MRD and MRD/white cell count interaction. (A) DFS according to TP1 MRD status in unselected patients; DFS according to TP1 MRD status and white blood cell (WBC) count (×10⁹/L) in (B) B-precursor ALL and (C) T-precursor ALL. DFS probability at 4 to 5 years: MRD^neg 0.63 versus MRD^low-pos (< ⁻⁴) 0.30 versus MRD^pos (≥⁻⁴) 0.15; B-precursor: MRD^neg 0.73 versus MRD^pos (any level) with WBC of 30 × 10⁹/L or less, 0.18 and WBC more than 30 × 10⁹/L, 0; T-precursor: MRD^neg 0.44 versus MRD^pos (any level) with WBC lower than or equal to or more than 100 × 10⁹/L, 0 (C).