TFS stratified by B-cell count greater than or less than 11 × 10⁹/L (panel A; n = 459; P = .001) and in conjunction with CD38 status (panel B; n = 436; P < .001), ZAP-70 status (panel C; n = 276; P < .001), IGHV gene mutation status (panel D; n = 275; P < .001), and by FISH risk category (E; n = 298; P < .001). For FISH risk category, those with either a 17p− or 11q− on FISH were considered to have an “unfavorable” FISH result while those with other FISH defects (eg, 13q−, trisomy 12, 6q−) or normal results on FISH were considered to have a “favorable” FISH result.