Elimination of IFN-γ in IL-2–KO mice delays AIHA development but does not alter lymphoproliferation. (A) Survival plots of WT, IL-2–KO, IFN-γ–KO, and IL-2/IFN-γ–KO mice. (B) Hematocrits (HCT) were measured from peripheral blood. (C) RBCs were stained with anti–mouse IgG-FITC to detect bound anti-RBC antibodies. There are no live IL-2–KO mice at 3 months; therefore, no data for these mice are shown at the late time point. Circles represent individual mice; n = 4 to 7 mice per genotype and time point. *P < .001; **P < .005.