αGalCer-activated iNKT cells enhance T-D B-cell response to protein vaccines in splenectomized mice. Splenectomized mice were vaccinated with NP-CGG with or without αGalCer 7 days after surgery, following the schedule in Figure S1. NP-specific IgG titers were determined. Asterisks indicate statistically significant differences (P ≤ .05) in antibody titers between groups of mice immunized with Ag alone or mixed with αGalCer. Shown are the results from 1 experiment representative of 2 in which 5 mice per group were tested. Results are shown as mean plus or minus SEM.