Figure 1
![Figure 1. Human FDP induce apoptosis in human JEG3 choriocarcinoma cells and vascular endothelial cells. (A) FDP induce in JEG3 cells nuclear condensation and fragmentation, and (B) DNA fragmentation as detected by TUNEL (green). (C,D) TUNEL stain of HUVECs cultured in the presence (C) or absence (D) of FDP. Nuclear stain with Hoechst 33 342; bar indicates 100 μm. (E) Caspase-3 amidolytic activity in cell extracts of JEG3 and HUVECs cultured for 48 hours without (cont) or with approximately 2.5 μM FDP. Bars represent mean (± standard error [SE]) from 3 independent experiments; n = 8 per experiment.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/113/18/10.1182_blood-2008-07-169433/6/zh80100931830001.jpeg?Expires=1735548691&Signature=RtPgRcHSNS49pJI5rmZTaZHuupSMnzyd1I1jRfu76p-gICkamCWlIi1vV5BNrCqPNX6dK0iBENeKNsJgMr8~FLs39njuWzptL1lDW1qGayoylu8W9gTe3jN-VhbOxPWjMmbywcx2U0yNmkrfRdji7e-GCGoeHS3a1UNDDfXsDH2JXKHgERDeMmw7PRnzWGBREDHlTS~HYNDWClVVJ7zxr~F3-iXRQV2RaOfYyY4rkgMcRXxMFXQ3tS2v5L25Lz1cbAZofUHxcBp2ETEP5LpjOC~0136FqxxQmgm2Q6BYHq3eMPDCajRr9GZM6y-itAO8mF9QtO3wTJMMl098PSCIdw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Human FDP induce apoptosis in human JEG3 choriocarcinoma cells and vascular endothelial cells. (A) FDP induce in JEG3 cells nuclear condensation and fragmentation, and (B) DNA fragmentation as detected by TUNEL (green). (C,D) TUNEL stain of HUVECs cultured in the presence (C) or absence (D) of FDP. Nuclear stain with Hoechst 33 342; bar indicates 100 μm. (E) Caspase-3 amidolytic activity in cell extracts of JEG3 and HUVECs cultured for 48 hours without (cont) or with approximately 2.5 μM FDP. Bars represent mean (± standard error [SE]) from 3 independent experiments; n = 8 per experiment.
