Summary of the genetic and clinical findings in our patients. (A) Schematic representation of the deleted regions on 21q22.12 (not drawn to scale). The deletion map was constructed using the USCS human genome browser (http://genome.ucsc.edu/). The black lines show the extents of the deletions. The shaded area is the overlap between the deletions in the 3 patients. The genes located within this interval are at the bottom of the figure. (B) Diagram of the shared and unique clinical features of the 3 patients described in this report.