Administration of anti-CTLA4 antibody and GM-CSF. (A) The dose of anti-CTLA4 antibody (mg/kg) and number of patients (n) on each dose level are presented. (B) The counts of CD4⁺ T cells per volume of blood were calculated by multiplying the percentage of CD4⁺ T cells by the absolute lymphocyte counts measured simultaneously. Each row represents the corresponding dose level. Each line represents the counts for each evaluable subject within the specified dose level.